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MSM has an excellent safety profile with rapid excretion and no reported equine toxicity, though horses with clotting disorders or on interacting medications should be managed in consultation with a veterinarian

However, these studies were constrained by the utilization of pooled-sample strategies, low throughput methods, or outdated platforms and technologies, which limited the scope of protein identification

They indicated that BroccoMax supplementation significantly reduced the tissue biomarkers, Ki-67 and HDAC3, in benign tissue but not in ductal carcinoma in situ (DCIS) or invasive ductal carcinoma breast tissues (Zhang et al., 2016), suggesting a role of sulforaphane in chemoprevention against breast cancer

This review aims to provide a theoretical foundation and innovative directions for the further development and clinical application of natural saponins in antitumor therapy, particularly in combination chemotherapy