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The mechanism involves enhanced lipolysis and reduced hepatic fat synthesis via improved insulin sensitivity

Targeting the Trem2-APOE pathway can restore the homeostatic signature of microglia in ALS and AD mouse models, potentially preventing neuronal loss and promote tolerogenic T-cell response (Krasemann et al., 2017)

10.1136/ard.2006.064287 117 OgataA.HiranoT.HishitaniY.TanakaT

Peptides like BPC57 have no literature supporting their role in treating conditions related to angioenesis, and their effects are likely overshadowed by hormonal factors, with no case reports or studies suggesting positive or negative central nervous system effects 10s