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Importantly, Ctnnb1 expression is spatiotemporally restricted, being detectable only in specific niches, such as in the hair germ during early anagen (Lien et al., 2014), which would be diluted in a whole-tissue lysate

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or the tumor is larger than 20 millimeters but not larger than 30 millimeters and may have spread to the edge of the eyelid where the lashes are, to the connective tissue in the eyelid, or to the full thickness of the eyelid

No published pharmacokinetic studies directly measure this interaction, making it impossible to quantify safe spacing or dosing adjustments