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At minimum: IGF-1 every 4 weeks, fasting glucose and insulin every 2 weeks initially (monthly once stable), HbA1c every 6 weeks, liver enzymes monthly, and comprehensive metabolic panel quarterly

PMID 8708844

Specifically, we analyzed affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and the hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete or incomplete infarcts (10% of area affected)