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The medications work through several complementary mechanisms: Appetite suppression : Acting on receptors in the hypothalamus to reduce hunger signals and increase satiety Delayed gastric emptying : Slowing the rate at which food leaves the stomach, prolonging feelings of fullness Enhanced insulin secretion : Stimulating glucose-dependent insulin release from pancreatic beta cells Reduced glucagon secretion : Decreasing the hormone that raises blood glucose levels Clinical efficacy for weight loss has been demonstrated in clinical trials