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LA exerts antiinflammatory effects through multiple pathways

Furthermore, GLP-1 and its analog (Ex-4) enhanced DNA repair and protected cortical neurons in brains of rats after ischemia which were due to up-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) mediated by PI3K/AKT/CREB pathway (100)

A pronounced difference was observed among mirtazapine users, with the mortality rate reaching 5.29% compared to 2.27% in non-users (HR, 2.05 [CI, 1.73 to 2.43]) (Fig

While most peptide research programs begin with a specific therapeutic target and build a synthetic molecule to match, this compound emerged from a fundamentally different direction: isolation and characterization of a naturally occurring protective sequence, followed by decades of systematic investigation into its biological activity profile