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Numerous endogenous agonists activate the GLP-1R, including several forms of GLP-1, oxyntomodulin and glucagon, and multiple exogenous peptide agonists are approved, or in clinical development, for the treatment of type 2 diabetes and/or obesity 1,2
Healthcare professionals and patients should be aware that individual responses may differ significantly from trial averages, and that fatigue persisting beyond a few weeks or worsening at any stage warrants clinical review
These drugs cost hundreds of dollars per month or sometimes more than $1,000 per month
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