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It is one of the most extensively studied copper-binding peptides in dermal and wound research literature, with published investigations spanning over four decades since its initial characterisation by Dr Loren Pickart in 1973

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While there is now increasing evidence for the use of chemical signals both for distance signaling (smell and odor) and for the sense of taste (gustation) in marine systems, our understanding of the chemical nature of the cues involved continues to be far behind our understanding of insect, vertebrate, and microbial cues (Wyatt, 2014)