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Due to limited research, the roles of GPx5, GPx6, and GPx8 in tumorigenesis are still awaiting clarification

In the liver, although both increased FFA uptake and upregulated de novo lipogenesis contribute to the development of hepatic steatosis, accumulating evidence suggests that increased FFA uptake plays a predominant role in the development of fatty livers 1

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However, because these observations rely solely on immunohistochemistry, they indicate potential involvement rather than providing definitive mechanistic evidence, and molecular validation is required to confirm these pathways