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Although GLP-2 can also blunt inflammatory cytokine production via inhibition of NF-B activity and ERK phosphorylation (63), enhanced macrophage accumulation was observed in the colon of colitic mice (35)

It is not recommended in patients with liver cirrhosis by fear of inducing lactic acidosis.42 However, this complication was reported only in anecdotal cases, particularly with concomitant alcohol intake.43 The use of this drug for the treatment of simple steatosis and NASH with or without DM has yielded conflicting results