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Studies suggest that IGF-1 LR3 might activate key signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) cascades, both of which are central to cellular proliferation and survival

Several of the medications showed that patients with a history of cardiac disease or risk factors for cardiovascular disease had lower risks of heart attacks, strokes, and myocardial infarctions when taking these agents compared to patients taking standard of care regardless of A1C lowering [35,36,37]

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