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Iron overload induces colitis by modulating ferroptosis and interfering gut microbiota in mice

CO is one of the elements of the Hemo-oxygenase 1-CO pathway, which has been proposed to constitute a defence system against oxidative and inflammatory damage [8]

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In addition, the marine polysaccharide fucoidan exemplifies broad pathway modulation: it can induce cancer cell apoptosis and cell cycle arrest, block metastasis and angiogenesis, and modulate various signaling molecules involved in tumor growth (133)