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DNA Deoxyribonucleic acid bases and phosphodiester backbones are susceptible to oxidative stress (inflammation), and peroxidation of these structures can cause strand breaks and cross-linking of the DNA and result in disrupted transcription, translation, and DNA replication It has been suggested that damaged genomic DNA of the spermatozoa can be transmitted to the offspring and lead to increased incidences of miscarriage, fetal anomalies, and birth defects They went on to show that treatment with Vitamin C and Glutathione reduced the level of hydroxy-2-deoxyguanosine which is a measure of DNA oxidative damage

10.1007/s13346-011-0050-2 74 HareD.AytonS.BushA.LeiP

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This integrated strategy aims to establish THC's therapeutic potential while identifying novel targets for antidepressant development