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Im Michael Gapen, Morgan Stanleys Chief U.S

In: Tulchinsky TH, Varavikova EA, Cohen MJ, editors

sometimes increases in HDL Liver : Improvements in fatty liver disease (reduced liver fat, improved liver enzymes) Cardiovascular Improvements : Blood Pressure : Significant reductions in systolic and diastolic blood pressure Cardiovascular Events : According to SELECT trial (semaglutide), 20% reduction in major cardiovascular events (heart attack, stroke, cardiovascular death) Heart Function : Improvements in cardiac structure and function markers Physical Function Improvements : Mobility : Improved ability to walk, climb stairs, engage in physical activities Joint Pain : Reduced knee, hip, and back pain from decreased weight-bearing stress Sleep : Improvements in sleep quality

This multi-target, multi-pathway paradigm overcomes the limitations of single-target drugs and highlights their potential for precision intervention in inflammatory disease