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Unfortunately, these study designs proved to be unsuccessful due in part to the excitotoxicity effect of NAC

Potency: In preclinical studies, Dihexa was found to be up to one million times more potent than BDNF in promoting synaptic connectivity highlighting its potential but also raising concerns about overstimulation

Since several ATGs and lysosomal cathepsin proteases depend on cysteines for their activities they can be the sensors or transducers of changes in the intracellular redox state through mechanisms involving redox signaling

One such antioxidant that has gained significant attention in recent years is Glutathione