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Furthermore, it has been shown that empagliflozin attenuates the decline of cardiac function in mice with HF in the absence of diabetes and that this is associated with reduced priming of NLRP3 inflammasome in the heart (Byrne et al., 2020)

It can be related to your body adjusting to the medication or dose adjustment

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Brain insulin resistance in Alzheimers disease and related disorders: Mechanisms and therapeutic approaches