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Efficacy and safety of liraglutide in patients with type 2 diabetes mellitus and severe obstructive sleep apnea

Primarily, hypothyroidism itself adversely affects gastrointestinal physiology by diminishing gastric mucosal integrity and reducing gastric acid secretion, thereby impairing the efficient absorption of nutrients and trace elements critical for thyroid function, such as selenium, iodine, iron, zinc, and vitamin D (Shulhai et al., 2024)

These include everolimus, a mechanistic target of rapamycin complex 1 inhibitor that modulates mitochondrial turnover, and idebenone, which bypasses complex I defects to directly transfer electrons

Furthermore, compound 8 reduced effusion in carrageenan-induced paw edema models of inflammation, while significantly lowering PGE2 concentrations