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This metabolic shift also impairs mitochondrial complex I function and reduces mitochondrial membrane potential (m), priming the organelle for subsequent injury (93)

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Monitor renal function Assess hydration status regularly Evaluate for gastrointestinal intolerance 14.2 Administration to Pregnant Women and Nursing Mothers 14.2.1 Risk-Benefit Assessment in Pregnancy Semaglutide is generally not recommended during pregnancy